Our research involves projects in bioinformatics and evolution, including: Development of the Clustal and T-Coffee programs for multiple sequence alignment. The use of multivariate statistical methods for analysis of microarray data. Using bioinformatics to identify promoters of human genes. Investigation of the molecular evolution of eukaryotic genomes, including the factors affecting intron evolution, and the relationships between animal phyla. Sequencing and comparative analysis of the bacterium Bifidobacterium breve.