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The factors affecting the molecular evolution of introns are poorly understood.
We are investigating the evolution of splice site strength, intron length, and
intron base composition in plant and animal protein-coding genes.
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The relationship between humans and the main model invertebrates, fruitflies and
nematodes is very controversial.
We are investigating the
relationship of these species using phylogenetic analyses of proteins.
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| Marie Fahey is investigating intron evolution. | Avril Coghlan is working on the relationship between animal phyla. |
| Fahey, M. E., Mills, W., Higgins, D. G. and Moore, T. F. (2005) Maternally and paternally silenced imprinted genes differ in their intron content. Comp. Functional Genomics (in press) | |
| Fahey, M. E., Moore, T. E. and Higgins, D. G. (2002) Overlapping antisense transcription in the human genome. Comp. Functional Genomics 3:244-253. | |