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One of the major challenges in deciphering the human genome is locating
the promoters that initiate transcription.
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We using bioinformatics methods to identify the promoters of human genes.
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| Stephen Madden is working on identification of binding sites in human promoters, especially those of kidney, eye and muscle-expressed genes. | Simon Furney is identifying trancription factor binding sites that are common in the promoters of human genes that are regulated by oncogenes. | Paul McGettigan is researching genes that are expressed in the human brain, and identification of their promoters. |
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Madden, S. F., O'Donovan, B., Furney, S. J., Brady, H. R., Silvestre, G. and Doran, P. P. (2003) Digital extractor: analysis of digital differential display output. Bioinformatics 19:1594-5 |